GRACEcast (lung-cancer-audio)
Expert oncologists provide brief, distilled summaries of the most central issues in cancer management and emerging approaches for patients and caregivers. The Global Resource for Advancing Cancer Education (GRACE) is committed to providing the knowledge that will help enable the general public to be informed participants in their own care. Visit cancerGRACE.org for more info.

Dr. David Spigel, Sarah Cannon Cancer Center, answers audience questions about squamous lung cancer.

Direct download: GRACEcast-182_Lung-Audio_Squamous_Lung_Cancer_Q_and_A_Session.mp3
Category:Lung-Cancer-Audio -- posted at: 12:34am PDT

Dr. David Spigel, Sarah Cannon Cancer Center, describes current research in immunotherapy as treatment for squamous lung cancer.

Direct download: GRACEcast-181_Lung-Audio_Squamous_Lung_Cancer_Immunotherapy.mp3
Category:Lung-Cancer-Audio -- posted at: 3:43pm PDT

Dr. David Spigel, Sarah Cannon Cancer Center, outlines treatment options for squamous lung cancer.

Direct download: GRACEcast-180_Lung-Audio_Squamous_Lung_Cancer_Treatment.mp3
Category:Lung-Cancer-Audio -- posted at: 3:07pm PDT

Dr. David Spigel, Sarah Cannon Cancer Center, discusses the importance of genomic testing in squamous lung cancer.

Direct download: GRACEcast-179_Lung-Audio_Squamous_Lung_Cancer_Genomic_Testing.mp3
Category:Lung-Cancer-Audio -- posted at: 10:02am PDT

Dr. David Spigel, Sarah Cannon Cancer Center, describes the diagnosis, presentation and workup of squamous lung cancer.


Dr. Edward Garon, David Geffen School of Medicine at UCLA, covers the provocative results of the novel immune checkpoint PD-L1 inhibitor MPDL3280A in advanced NSCLC.

Direct download: GRACEcast-172_Lung-Audio_ASCO_2013_MPDL3280A_NSCLC.mp3
Category:Lung-Cancer-Audio -- posted at: 12:32pm PDT

Dr. Edward Garon, David Geffen School of Medicine at UCLA, reviews impressive results from the GALAXY-1 trial of the heat shock protein inhibitor ganetespib combined with combined with second line docetaxel in advanced lung adenocarcinoma.

Direct download: GRACEcast-171_Lung-Audio_ASCO_2013_Ganetespib_Second_Line.mp3
Category:Lung-Cancer-Audio -- posted at: 6:56pm PDT

Dr. Edward Garon, David Geffen School of Medicine at UCLA, discusses results in a trial that demonstrated a significant survival benefit with nintedanib combined with second line docetaxel in advanced lung adenocarcinoma.

Direct download: GRACEcast-170_Lung-Audio_ASCO_2013_Nintedanib_Second_Line.mp3
Category:Lung-Cancer-Audio -- posted at: 4:56pm PDT

Dr. Edward Garon, David Geffen School of Medicine at UCLA, describes the exciting developments with LDK-378 and potentially other second generation ALK inhibitors for crizotinib-resistant ALK-positive advanced NSCLC.


Dr. Edward Garon, David Geffen School of Medicine at UCLA, covers the results and implications of the MADeIT phase III randomized study of preductive biomarkers ERCC1 and RRM1 in advanced NSCLC.

Direct download: GRACEcast-168_Lung-Audio_ASCO_2013_MADeIT_ERCC1_RRM1.mp3
Category:Lung-Cancer-Audio -- posted at: 11:48am PDT

Dr. Edward Garon, David Geffen School of Medicine at UCLA, reviews the landmark Biomarkers France study that tested a wide range of molecular markers in NSCLC.

Direct download: GRACEcast-167_Lung-Audio_ASCO_2013_Biomarkers_France.mp3
Category:Lung-Cancer-Audio -- posted at: 11:46am PDT

Dr. David Gerber, University of Texas-Southwestern, discusses the key results and potential implications of the CALGB 30504 trial of maintenance sunitinib for extensive stage SCLC.


Dr. David Gerber, University of Texas-Southwestern, reviews the results of the PROSE study of the Veristrat serum proteomics test to predict benefit of chemo or EGFR inhibitor for second line treatment of advanced lung cancer.

Direct download: GRACEcast-165_Lung-Audio_ASCO_2013_Veristrat_PROSE.mp3
Category:Lung-Cancer-Audio -- posted at: 2:18pm PDT

Dr. David Gerber, University of Texas-Southwestern, discusses results of two important trials of maintenance therapy in advanced NSCLC, including the PRONOUNCE trial and POINTBREAK trials.


Dr. David Gerber, University of Texas-Southwestern, reviews a Swiss study comparing tri-modality therapy with chemoradiation followed by surgery to chemo followed by surgery for stage IIIA NSCLC.


Dr. David Gerber, University of Texas-Southwestern, reviews results of the START trial of tecemotide immunotherapy for stage III unresectable NSCLC.


Dr. David Gerber, University of Texas-Southwestern, reviews results from RTOG 0617 that help clarify the optimal dose of radiation for stage III unresectable NSCLC.


Dr. David Gerber, University of Texas-Southwestern, reviews the current questions in managing locally advanced NSCLC with chemo/radiation as introduction to key issues addressed in trials from ASCO 2013.

Direct download: GRACEcast-159_Lung-Audio_ASCO_2013_Intro_to_Stage_III_NSCLC.mp3
Category:Lung-Cancer-Audio -- posted at: 10:08pm PDT

Dr. Antoinette (Toni) Wozniak from Karmanos Cancer Center in Detroit, MI discusses the evolution of our current best treatments for limited and extensive stage small cell lung cancer, as well as emerging potential therapies.


Dr. Antoinette (Toni) Wozniak from Karmanos Cancer Center in Detroit, MI reviews the impact, causes, common symptoms, and approach to staging of small cell lung cancer.


Dr. Johannes Kratz, surgeon at Massachusetts General Hospital, reviews data supporting a method to define prognosis in early stage non-small cell lung cancer (NSCLC) based on molecular signatures and proposes a new staging system.


Dr. Johannes Kratz, surgeon at Massachusetts General Hospital, reviews early efforts in molecularly-defined staging of patients with early stage non-small cell lung cancer (NSCLC).


Dr. Johannes Kratz, surgeon at Massachusetts General Hospital, explains the potential utility of molecularly guided staging of patients with early stage non-small cell lung cancer (NSCLC).


Dr. Natasha Leighl, Princess Margaret Hospital in Toronto, Canada, summarizes evidence from the PARAMOUNT trial, demonstrating a survival benefit for continuation maintenance therapy with Alimta (Pemetrexed) in advanced non-small cell lung cancer.


Dr. Natasha Leighl, Princess Margaret Hospital in Toronto, Canada, describes new targets for squamous cell non-small cell lung cancer and anti-PD1 immunotherapy that has emerged as one of the most promising new developments in lung cancer from 2012.

Direct download: GRACEcast-145_Lung-Audio_Leighl_Highlights_Squam_and_antiPD1.mp3
Category:Lung-Cancer-Audio -- posted at: 6:31pm PDT

Dr. Natasha Leighl, Princess Margaret Hospital in Toronto, Canada, reviews exciting new data illustrating the potential benefits of the MEK inhibitor selumetinib in treating KRAS mutation-positive advanced non-small cell lung cancer.

Direct download: GRACEcast-144_Lung-Audio_Leighl_Highlights_MEK_KRAS_Mutation.mp3
Category:Lung-Cancer-Audio -- posted at: 4:46pm PDT

Dr. Natasha Leighl, Princess Margaret Hospital in Toronto, Canada, describes emerging data on the efficacy of ALK inhibitors for patients with advanced NSCLC that harbors an ALK or ROS1 rearrangement.

Direct download: GRACEcast-141_Lung-Audio_Leighl_Highlights_in_LC_2012_Part_2.mp3
Category:Lung-Cancer-Audio -- posted at: 8:04pm PDT

Dr. Natasha Leighl, Princess Margaret Hospital in Toronto, Canada, reviews new data supporting new treatment options for EGFR mutation-positive patients with advanced NSCLC being newly treated or developing acquired resistance to prior EGFR inhibitors.

Direct download: GRACEcast-140_Lung-Audio_Leighl_Highlights_in_LC_2012_Part_1.mp3
Category:Lung-Cancer-Audio -- posted at: 4:58pm PDT

Dr. David Harpole of Duke University reviews advances in lung cancer surgery, covering techniques ranging from video-assisted thoracic surgery to robotic surgery to sub-lobar resections and other developments offering new promising alternatives.

Direct download: GRACEcast-139_Lung-Audio_Advances_in_LC_Surgical_Techniques.mp3
Category:Lung-Cancer-Audio -- posted at: 3:29pm PDT

Dr. David Harpole of Duke University reviews advances in lung cancer surgery, focusing in this first part on the evolution of techniques to improve staging of lung cancer.

Direct download: GRACEcast-138_Lung-Audio_Advances_in_Lung_Cancer_Staging.mp3
Category:Lung-Cancer-Audio -- posted at: 2:51pm PDT

Dr. Gerard Silvestri, pulmonologist from Medical University of South Carolina (MUSC) in Charleston, reviews the subject of pneumonitis (inflamation of the lung tissue) induced by EGFR inhibitors or chest radiation.

Direct download: GRACEcast-120_Lung-Audio_Pulmonary_Complications_of_LC_2.mp3
Category:Lung-Cancer-Audio -- posted at: 7:15pm PDT

Dr. Gerard Silvestri, pulmonologist from Medical University of South Carolina (MUSC) in Charleston, reviews the subject of pneumonitis (inflamation of the lung tissue) induced by chemotherapy commonly used for treating lung cancer.

Direct download: GRACEcast-119_Lung-Audio_Pulmonary_Complications_of_LC.mp3
Category:Lung-Cancer-Audio -- posted at: 7:33pm PDT

Drs. Mark Socinski from Univ. of Pittsburgh and Joel Neal from Stanford Cancer Center answer questions about topics covered in the summary of lung cancer highlights from ASCO 2012.

Direct download: GRACEcast-118_Lung-Audio_ASCO_2012_Q_and_A_10.mp3
Category:Lung-Cancer-Audio -- posted at: 12:30pm PDT

Dr. Joel Neal presents interesting early data demonstrating that squamous NSCLC often features identifiable molecular markers that can potentially be targeted by novel therapies.

Direct download: GRACEcast-117_Lung-Audio_ASCO_2012_Neal_9.mp3
Category:Lung-Cancer-Audio -- posted at: 8:00am PDT

Dr. Joel Neal summarizes preliminary results of the SELECT trial of adjuvant Tarceva (erlotinib) for patients with resected EGFR mutation-positive early stage non-small cell lung cancer. 

Direct download: GRACEcast-116_Lung-Audio_ASCO_2012_Neal_8.mp3
Category:Lung-Cancer-Audio -- posted at: 4:11pm PDT

Dr. Joel Neal covers results with afatinib, an irreversible "pan-HER inhibitor", compared with standard chemo for patients with advanced NSCLC and an EGFR mutation.

Direct download: GRACEcast-115_Lung-Audio_ASCO_2012_Neal_7.mp3
Category:Lung-Cancer-Audio -- posted at: 12:29am PDT

Dr. Joel Neal reviews the favorable results with chemo combined with the novel targeted therapy selumetinib, a MEK inhibitor, in KRAS mutatino-positive patients with advanced non-small cell lung cancer (NSCLC).

Direct download: GRACEcast-114_Lung-Audio_ASCO_2012_Neal_6.mp3
Category:Lung-Cancer-Audio -- posted at: 8:56pm PDT

Dr. Joel Neal describes the very encouraging data on anti-PD-1 immunotherapy with BMS-936558/MDX-1106 in patients with advanced non-small cell lung cancer (NSCLC).

Direct download: GRACEcast-113_Lung-Audio_ASCO_2012_Neal_5.mp3
Category:Lung-Cancer-Audio -- posted at: 5:01pm PDT

Dr. Mark Socinski reviews key results in small cell lung cancer (SCLC) from ASCO 2012, including the SWOG 0802 trial of topotecan +/- VEGF inhibitor aflibercept and a Japanese randomized trial of cisplatin/amrubicin vs. cisplatin/irinotecan.

Direct download: GRACEcast-112_Lung-Audio_ASCO_2012_Socinski_4.mp3
Category:Lung-Cancer-Audio -- posted at: 6:00pm PDT

Dr. Mark Socinski from University of Pittsburgh summarizes and critiques the TAILOR trial of Taxotere (docetaxel) vs. Tarceva (erlotinib) in EGFR wild type advanced NSCLC.

Direct download: GRACEcast-111_Lung-Audio_ASCO_2012_Socinski_3.mp3
Category:Lung-Cancer-Audio -- posted at: 8:45pm PDT

Dr. Mark Socinski from the University of Pittsburgh reviews evidence to support doublet chemo over single agent for marginal performance status (PS2) patients with advanced NSCLC.

Direct download: GRACEcast-110_Lung-Audio_ASCO_2012_Socinski_2.mp3
Category:Lung-Cancer-Audio -- posted at: 12:43am PDT

Dr. Mark Socinski from the University of Pittsburgh reviews the survival benefit and implications from the PARAMOUNT maintenance therapy trial of Alimta (pemetrexed) in advanced NSCLC.

Direct download: GRACEcast-109_Lung-Audio_ASCO_2012_Socinski_1.mp3
Category:Lung-Cancer-Audio -- posted at: 3:13pm PDT

Drs. Ramaswamy Govindan from Washington University and Julie Brahmer from Johns Hopkins University answer questions about the current evidence and emerging research on immune-based treatments for lung cancer.

Direct download: GRACEcast-104_Lung-Audio_Immunotherapies_Q_and_A.mp3
Category:Lung-Cancer-Audio -- posted at: 1:35pm PDT

Dr. Julie Brahmer reviews science and early trial results for immunotherapies for lung cancer ranging from cancer vaccines to anti-cancer viruses.

Direct download: GRACEcast-103_Lung-Audio_Brahmer_on_Immunotherapies.mp3
Category:Lung-Cancer-Audio -- posted at: 10:36am PDT

Dr. Ramaswamy Govindan provides a summary of the science behind several promising immunotherapies for lung cancer and the clinical trials that could lead to them being integrated into our treatment plans.

Direct download: GRACEcast-102_Lung-Audio_Govindan_on_Immunotherapies.mp3
Category:Lung-Cancer-Audio -- posted at: 11:58pm PDT

Dr. Glen Goss, University of Ottawa and NCI-Canada Lung Cancer Committee chair, discusses the potential and limitations of integrating molecular marker studies in advanced non-small cell lung cancer patients across a health care system.

Direct download: GRACEcast-101_Lung-Audio_MMiLC_Panel_Discussion_pt6.mp3
Category:Lung-Cancer-Audio -- posted at: 11:00pm PDT

Dr. David Spigel, Sarah Cannon Cancer Center, discusses the benefits and challenges of conducting trials that include patient subgroups based on molecular markers.

Direct download: GRACEcast-100_Lung-Audio_MMiLC_Panel_Discussion_pt5.mp3
Category:Lung-Cancer-Audio -- posted at: 3:22pm PDT

Panel discussion with 4 expert thought leaders in lung cancer about how we might best approach testing clinically relevant molecular targets in lung cancer patients.

Direct download: GRACEcast-099_Lung-Audio_MMiLC_Panel_Discussion_pt4.mp3
Category:Lung-Cancer-Audio -- posted at: 4:52pm PDT

Panel discussion with 4 expert thought leaders in lung cancer about the prevalence of critical molecular markers in different clinical and histologic groups of lung cancer patients.

Direct download: GRACEcast-098_Lung-Audio_MMiLC_Panel_Discussion_pt3.mp3
Category:Lung-Cancer-Audio -- posted at: 7:05pm PDT

Dr. Alice Shaw from Massachusetts General Hospital reviews the frequency of molecular markers in lung cancer by patient sex, smoking status, race, and histology.

Direct download: GRACEcast-097_Lung-Audio_MMiLC_Shaw_on_Patterns_pt2.mp3
Category:Lung-Cancer-Audio -- posted at: 4:04pm PDT

Dr. Charles Rudin from Johns Hopkins covers the work from the Lung Cancer Mutation Consortium that identified a wide range of molecular markers in patients with lung adenocarcinoma.

Direct download: GRACEcast-096_Lung-Audio_MMiLC_Rudin_on_Consortium_pt1.mp3
Category:Lung-Cancer-Audio -- posted at: 4:58pm PDT

Q and A session with Dr. Jared Weiss, Medical Oncologist at UNC-Chapel Hill, about highlights in lung cancer in 2011.

Direct download: GRACEcast-095_Lung-Audio_2011_Lung_Cancer_Highlights_pt4.mp3
Category:Lung-Cancer-Audio -- posted at: 3:40pm PDT

Dr. Jared Weiss, Medical Oncologist at UNC-Chapel Hill, reviews lung cancer highlights in 2011, here describing evidence supporting lung cancer screening by chest CT, as well as evidence on how best to treat elderly patients with advanced lung cancer.

Direct download: GRACEcast-094_Lung-Audio_2011_Lung_Cancer_Highlights_pt3.mp3
Category:Lung-Cancer-Audio -- posted at: 8:00am PDT

Dr. Jared Weiss, Medical Oncologist at UNC-Chapel Hill, reviews lung cancer highlights in 2011, with this podcast focusing on ALK rearrangements and new molecular targets in lung cancer.

Direct download: GRACEcast-093_Lung-Audio_2011_Lung_Cancer_Highlights_pt2.mp3
Category:Lung-Cancer-Audio -- posted at: 8:00am PDT

The GRACEcast feeds on iTunes are moving!

Direct download: GRACEcast-092_Lung-Cancer-Audio_GRACEcast_Feeds_Moving.mp3
Category:Lung-Cancer-Audio -- posted at: 2:58pm PDT

Dr. Jared Weiss, Medical Oncologist at UNC-Chapel Hill, reviews lung cancer highlights in 2011, focusing here on treatments focusing on the EGFR axis.

Direct download: GRACEcast-091_Lung-Audio_2011_Lung_Cancer_Highlights.mp3
Category:Lung-Cancer-Audio -- posted at: 6:26pm PDT

Dr. Mark Millard, Pulmonologist at Baylor University, describes how to approach smoking cessation and a range of tools for helping smokers who are motivated to quit.

Direct download: GRACEcast-090_Lung-Audio_Millard_on_Smoking_Cessation.mp3
Category:Lung-Cancer-Audio -- posted at: 1:39am PDT

Dr. Mark Millard, Pulmonologist at Baylor University, reviews the history of tobacco in North America, early research leading to the association of tobacco with lung cancer, and a discussion of how lung cancer prevalence follows patterns of tobacco use.

Direct download: GRACEcast-089_Lung-Audio_Millard_on_History_of_Tobacco.mp3
Category:Lung-Cancer-Audio -- posted at: 7:39pm PDT

Case-based discussion with multiple lung cancer experts on optimal treatment of a patient with advanced lung adenocarcinoma, EGFR mutation, & now acquired resistance to EGFR TKI after very good prior response.

Direct download: GRACEcast-088_Lung-Audio_CCILC_Acquired_Resistance.mp3
Category:Lung-Cancer-Audio -- posted at: 10:21am PDT

Dr. David Yankelevitz, Professor of Radiology at Mount Sinai Medical Center in New York City, reviews technical advances in CT screening for lung nodules, features  suggesting whether a nodule is benign or malignant, and the CT-guided biopsy procedure.

Direct download: GRACEcast-087_Lung-Audio_Yankelevitz_on_Lung_Nodules.mp3
Category:Lung-Cancer-Audio -- posted at: 10:49pm PDT

Drs. Ben Solomon (Peter MacCallum Cancer Center in Melbourne) and Ross Camidge (Univ. of Colorado) answer Qs on ALK rearrangements and crizotinib (XALKORI) for advanced non-small cell lung cancer (NSCLC).

Direct download: GRACEcast-086_Lung-Audio_Solomon_Camidge_ALK_QnA.mp3
Category:Lung-Cancer-Audio -- posted at: 8:00am PDT

Dr. Ross Camidge reviews considerations of who to screen for an ALK rearrangement and additional treatment alternatives for patients with ALK-positive advanced non-small cell lung cancer.

Direct download: GRACEcast-085_Lung-Audio_Camidge_on_ALK-Positive.mp3
Category:Lung-Cancer-Audio -- posted at: 5:30pm PDT

Dr. Ben Solomon of Peter MacCallum Cancer Centre in Melbourne Australia reviews ALK Inhibition from mechanism of action to activity and side effect profile of crizotinib, newly approved for patients with ALK-positive advanced non-small cell lung cancer.

Direct download: GRACEcast-084_Lung-Audio_Solomon_on_ALK_Inhibition.mp3
Category:Lung-Cancer-Audio -- posted at: 11:49pm PDT

Dr. Rogerio Lilenbaum, lung cancer expert, medical oncologist, & Chairman of Cleveland Clinic Florida, answers questions on special management considerations for elderly and frail patients with lung cancer.

Direct download: GRACEcast-083_Lung-Audio_Lilenbaum_Elderly_QnA.mp3
Category:Lung-Cancer-Audio -- posted at: 4:22pm PDT

Dr. Rogerio Lilenbaum, medical oncologist and Chair of Heme/Onc at Cleveland Clinic in Weston, FL, reviews evidence on how age and other medical problems should be incorporated into management of lung cancer.

Direct download: GRACEcast-082_Lung-Audio_Lilenbaum_on_Elderly_Treatment.mp3
Category:Lung-Cancer-Audio -- posted at: 1:18am PDT

Dr. Mario Lacouture, expert dermatologist at Memorial Sloan-Kettering Cancer Center in NYC,  answers questions on management of side effects related to skin, hair, and nails for patients on cancer treatments that cause dermatologic complications.

Direct download: GRACEcast-081_CA-Rx-Audio_Lacouture_Skin_QnA.mp3
Category:Lung-Cancer-Audio -- posted at: 7:17pm PDT

Case-based discussion with multiple lung cancer experts on the controversial question of whether to recommend consolidation chemotherapy after concurrent chemotherapy and radiation for locally advanced NSCLC.

Direct download: GRACEcast-079_Lung-Audio_CCILC_Unresectable_NSCLC.mp3
Category:Lung-Cancer-Audio -- posted at: 8:00am PDT

Question and answer session with Drs. Mary Pinder-Schenck from Moffitt Cancer Center in Tampa and Nasser Hanna from Indiana University about highlights in lung cancer from ASCO 2011 annual meeting.

Direct download: GRACEcast-078_Lung-Audio_ASCO_2011_Highlights_QnA.mp3
Category:Lung-Cancer-Audio -- posted at: 3:01pm PDT

Dr. Nasser Hanna from Indiana University Cancer Center reviews highlights of presentations on advanced/metastatic NSCLC from the ASCO 2011 annual meeting.

Direct download: GRACEcast-077_Lung-Audio_ASCO_2011_Highlights_2.mp3
Category:Lung-Cancer-Audio -- posted at: 2:04pm PDT

Dr. Mary Pinder-Schenck from the H. Lee Moffitt Cancer Center in Tampa, FL reviews highlights of presentations on small cell lung cancer, early stage non-small cell lung cancer, and mesothelioma from the ASCO 2011 meeting.

Direct download: GRACEcast-076_Lung-Audio_ASCO_2011_Highlights.mp3
Category:Lung-Cancer-Audio -- posted at: 8:31pm PDT

Case-based discussion with multiple lung cancer experts on the optimal treatment of a patient with multi-station N2 node-positive squamous cell NSCLC, including whether surgery should be pursued.

Direct download: GRACEcast-075_Lung-Audio_CCILC_Node-Positive_NSCLC.mp3
Category:Lung-Cancer-Audio -- posted at: 8:00am PDT

Case-based discussion with multiple lung cancer experts on whether to recommend post-operative (adjuvant) chemotherapy for a patient with a less than 4 cm non-small cell lung cancer (NSCLC) tumor with some high risk features.

Direct download: GRACEcast-074_Lung-Audio_CCILC_Node-Negative_NSCLC.mp3
Category:Lung-Cancer-Audio -- posted at: 8:00am PDT

Case-based discussion with multiple lung cancer experts on whether to recommend post-operative (adjuvant) chemotherapy for a patient with small non-small cell lung cancer (NSCLC) tumor with satellite lesions.

Direct download: GRACEcast-073_Lung-Audio_CCILC_Satellite_Nodules.mp3
Category:Lung-Cancer-Audio -- posted at: 2:17pm PDT

Question and answer session with Dr. Minesh Mehta, Professor of Radiation Oncology at Northwestern University, on topics related to treatments for brain metastases and related complications, especially in the setting of lung cancer.

Direct download: GRACEcast-072_Lung-Audio_Mehta_on_Brain_Mets_QnA.mp3
Category:Lung-Cancer-Audio -- posted at: 12:11am PDT

Dr. Minesh Mehta, Professor of Radiation Oncology at Northwestern University, describes benefits and risks of multiple interventions that are currently used or being studied to reduce risk of developing brain metastases or treat established metastases.

Direct download: GRACEcast-071_Lung-Audio_Mehta_on_Brain_Metastases.mp3
Category:Lung-Cancer-Audio -- posted at: 8:00am PDT

Dr. Lecia Sequist of Massachusetts General Hospital answers questions about acquired resistance to EGFR tyrosine kinase inhibitors and repeat biopsies of tumors over the course of treatment for advanced NSCLC.

Direct download: GRACEcast-070_Lung-Audio_Sequist_EGFR_TKI_QnA.mp3
Category:Lung-Cancer-Audio -- posted at: 8:00am PDT

Dr. Lecia Sequist of Massachusetts General Hospital describes the results of their experience in repeating biopsies in patients over the course of their ongoing treatment for advanced NSCLC and the changes in tumor characteristics over time.

Direct download: GRACEcast-069_Lung-Audio_Sequist_on_Re-Biopsying_Results.mp3
Category:Lung-Cancer-Audio -- posted at: 8:00am PDT

Dr. Lecia Sequist of Massachusetts General Hospital presents a summary of the challenge of acquired resistance to EGFR tyrosine kinase inhibitors like Tarceva (erlotinib) and Iressa (gefitinib), along with emerging ideas for overcoming it.

Direct download: GRACEcast-068_Lung-Audio_Sequist_on_EGFR_Resistance.mp3
Category:Lung-Cancer-Audio -- posted at: 8:00am PDT

Case discussion with Drs. Tom Hensing of in Chicago & David Jackman in Boston, discussing practical issues around molecular marker testing & recommended treatments for first line & maintenance therapy for a never-smoker with a lung adenocarcinoma.

Direct download: GRACEcast-067_Lung-Audio_ERT_NSCLC_Markers_Case_3.mp3
Category:Lung-Cancer-Audio -- posted at: 5:00am PDT

Case discussion with Drs. Tom Hensing of in Chicago and David Jackman in Boston, discussing practical issues around molecular marker testing and recommended treatments for first line and maintenance therapy for an ex-smoker with a lung adenocarcinoma.

Direct download: GRACEcast-066_Lung-Audio_ERT_NSCLC_Markers_Case_2.mp3
Category:Lung-Cancer-Audio -- posted at: 5:00am PDT

Expert Round Table with Drs. Hensing and Jackman on Molecular Markers and Sequencing of Therapy for Advanced NSCLC (audio)

Case discussion with Drs. Tom Hensing of in Chicago and David Jackman in Boston, discussing practical issues around molecular marker testing and recommended treatments for first line and maintenance therapy for a patient with advanced squamous cell NSCLC.

Direct download: GRACEcast-065_Lung-Audio_ERT_NSCLC_Markers.mp3
Category:Lung-Cancer-Audio -- posted at: 5:00am PDT

Expert Round Table on Bulky Unresectable Stage IIIB NSCLC and the Outer Limits of Curative Intent (audio)

Case discussion with Drs. George Blumenschein of MD Anderson and Walter Curran of Emory University, reviewing concerns about risks of aggressive treatment of bulky locally advanced NSCLC and potential management strategies.

Direct download: GRACEcast-061_Lung-Audio_ERT_Stage_IIIB_Curative_Intent.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

Expert Round Table on Ambiguous Imaging Results and Subsequent Treatment after Chemo/Radiation (audio)

Case discussion with Drs. George Blumenschein of MD Anderson and Walter Curran of Emory University, covering management approaches for a stage IIIB locally advanced NSCLC with ambiguous imaging results after chemo and radiation were completed.

Direct download: GRACEcast-059_Lung-Audio_ERT_Ambiguous_Imaging.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

Expert Round Table on Stage IIIA N2 Node-Positive NSCLC: Options for Surgical and Non-Surgical Management (audio)

Case discussion with Drs. George Blumenschein of MD Anderson Cancer Center and Walter Curran of Emory University, reviewing management options for the range of treatment approaches for patients with stage IIIA N2, locally advanced NSCLC.

Direct download: GRACEcast-058_Lung-Audio_ERT_Stage_IIIA_N2_Options.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

Expert Round Table on Managing Advanced Non-Small Cell Lung Cancer (NSCLC) in Elderly and Frail Patients (audio)

Case discussion with Drs. Paul Hesketh of the Lahey Clinic and Karen Kelly of Kansas University Medical Center, covering question of optimal treatment for patients with advanced NSCLC who are elderly or have a marginal performance status.

Direct download: GRACEcast-057_Lung-Audio_ERT_Adv_NSCLC_in_Elderly.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

Expert Round Table on Managing Locally Advanced NSCLC in Elderly and Frail Patients (audio)

Case discussion with Drs. Paul Hesketh of the Lahey Clinic and Karen Kelly of Kansas University Medical Center, discussing options for administering multimodality therapy for stage III NSCLC in patients who are elderly or have a marginal performance status.

Direct download: GRACEcast-056_Lung-Audio_ERT_Management_for_Elderly.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

Expert Round Table on Considerations for Adjuvant Therapy in Elderly and Frail Patients (audio)

Case discussion with Drs. Paul Hesketh of the Lahey Clinic and Karen Kelly of Kansas University Medical Center, discussing current evidence and challenges of post-operative treatments for early stage NSCLC in elderly and/or frail patients.

Direct download: GRACEcast-055_Lung-Audio_ERT_Therapy_for_Elderly.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

Q and A Session on Maintenance Therapy for Advanced NSCLC: When, What, Why, and What’s Left After Post-Maintenance Relapse? (audio)

Dr. Mark Socinski, medical oncologist and leader of the Thoracic Oncology Program at Univ. of North Carolina, answers questions about what treatments to recommend after first line therapy for advanced NSCLC and when they should be pursued.

Direct download: GRACEcast-054_Lung-Audio_Socinski_NSCLC_Maint_QnA.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

Maintenance Therapy for Advanced NSCLC: When, What, Why, and What’s Left After Post-Maintenance Relapse? (audio)

Dr. Mark Socinski, medical oncologist and leader of the Thoracic Oncology Program at Univ. of North Carolina, summarizes the evidence and presents a current approach to managing treatment of advanced NSCLC after first line therapy.

Direct download: GRACEcast-053_Lung-Audio_Socinski_on_NSCLC_Maint.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

Should Surgery be Considered for Very Limited Small Cell Lung Cancer? (audio)

Dr. Howard (Jack) West, medical oncologist, President & CEO of GRACE, reviews the debate about whether surgery should have a role in managing early small cell lung cancer (SCLC).

Direct download: GRACEcast-052_Lung-Audio_West_on_SCLC_Surgery.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

Q and A with Dr. Suresh Ramalingam on Individualizing First Line Therapy for Advanced NSCLC (audio)

Dr. Suresh Ramalingam, medical oncologist and leader of the Thoracic Oncology Program at Emory University, discusses questions about individualizing therapy choices for patients with advanced NSCLC.

Direct download: GRACEcast-051_Lung-Audio_Ramalingam_on_First_Line_2.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

Individualizing First Line Therapy for Advanced NSCLC, by Dr. Suresh Ramalingam (audio)

Dr. Suresh Ramalingam, medical oncologist and leader of the Thoracic Oncology Program at Emory University, reviews the evolution of first line treatment of advanced non-small cell lung cancer to our current tailored approach for optimal outcomes.

Direct download: GRACEcast-050_Lung-Audio_Ramalingam_on_First_Line.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

The Role of EGFR Inhibitor Therapy as Post-Operative Treatment for Early Stage NSCLC: A Controversial Question (audio)

Dr. Jared Weiss, medical oncologist from the Univ. of Pennsylvania, covers limited data and current clinical trials addressing potential role of EGFR inhibitors, and particularly Tarceva (erlotinib), as post-surgical treatment for advanced NSCLC.

Direct download: GRACEcast-049_Lung-Audio_Weiss_EGFR_for_NSCLC.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

Expert Round Table with Drs. Anne Tsao and Alex Farivar: Case Discussion on Isolated Brain Metastasis (audio)

Case discussion with Dr. Anne Tsao of medical oncology at MD Anderson, and Dr. Alex Farivar of thoracic surgery at Swedish Cancer Institute, on a case of man with an isolated brain metastasis being considered for curative therapy.

Direct download: GRACEcast-048_Lung-Audio_ERT_Tsao_Farivar_Case_3.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

Case Discussion with Experts, Drs. Julie Brahmer and Greg Riely: Case 1 (audio)

Case discussion with Dr. Julie Brahmer of Johns Hopkins University and Dr. Gregory Riely of Memorial Sloan Kettering, on a case of a woman with poorly differentiated NSCLC, responding well to fist line chemotherapy.

Direct download: GRACEcast-047_Lung-Audio_CDE_Brahmer_Riely_Case_1.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

Q and A Session on The Emerging Role of Molecular Markers in NSCLC: a Webinar by Dr. Nathan Pennell (audio)

Q&A Session following webinar with Dr. Nathan Pennell, medical oncologist and lung cancer expert at the Cleveland Clinic Foundation, on the use of molecular markers such as EGFR, KRAS, ERCC-1, EML4-ALK, and others in NSCLC.

Direct download: GRACEcast-046_Lung-Audio_Pennell_NSCLC_Markers_2.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

Expert Round Table with Drs. Anne Tsao and Alex Farivar: Case Discussion on Malignant Pleural Mesothelioma (audio)

Case discussion with Dr. Anne Tsao of medical oncology at MD Anderson, and Dr. Alex Farivar of thoracic surgery at Swedish Cancer Institute, on a case of a relatively fit man with malignant pleural mesothelioma.

Direct download: GRACEcast-045_Lung-Audio_ERT_Tsao_Farivar_Case_2.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

ALK gene rearrangements, ALK inhibitors, and the Lung Cancer Revolution, by Dr. D. Ross Camidge (audio)

Dr. D. Ross Camidge, medical oncologist at the University of Colorado, provides an overview of the newly identified ALK gene rearrangements, novel therapy to target this, and the promise of molecular oncology.

Direct download: GRACEcast-044_Lung-Audio_Camidge_on_ALK.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

Expert Round Table with Drs. Anne Tsao and Alex Farivar: Case Discussion on Indolent BornchioloAlveolar Carcinoma (BAC) (audio)

Case discussion of management options for an elderly man with slowly progressing BAC, with Dr. Anne Tsao of medical oncology at MD Anderson, and Dr. Alex Farivar of thoracic surgery at Swedish Cancer Institute.

Direct download: GRACEcast-043_Lung-Audio_ERT_Tsao_Farivar_BAC_1.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT

Interview with Dr. Kristin Manning, Part 1: Screening, Workup, and Follow-Up of Lung Cancer (audio)

Dr. Kristin Manning, expert radiologist at Seattle Radiology, discusses work on lung cancer screening, the features of a pulmonary nodule that raise and lower suspicion for lung cancer, and other aspects of initial and follow-up imaging for lung cancer.

Direct download: GRACEcast-041_Lung-Audio_Manning_Screening_Workup_1.mp3
Category:Lung-Cancer-Audio -- posted at: 5:02am PDT