GRACEcast
Expert oncologists provide brief, distilled summaries of the most central issues in cancer management and emerging approaches for patients and caregivers. The Global Resource for Advancing Cancer Education (GRACE) is committed to providing the knowledge that will help enable the general public to be informed participants in their own care. Visit cancerGRACE.org for more info.

Dr. David Spigel, Sarah Cannon Cancer Center, answers audience questions about squamous lung cancer.

Direct download: GRACEcast-182_Lung-Video_Squamous_Lung_Cancer_Q_and_A_Session.m4v
Category:Lung-Cancer-Video -- posted at: 12:35am PDT

Dr. David Spigel, Sarah Cannon Cancer Center, answers audience questions about squamous lung cancer.

Direct download: GRACEcast-182_Lung-Audio_Squamous_Lung_Cancer_Q_and_A_Session.mp3
Category:Lung-Cancer-Audio -- posted at: 12:34am PDT

Dr. David Spigel, Sarah Cannon Cancer Center, describes current research in immunotherapy as treatment for squamous lung cancer.

Direct download: GRACEcast-181_Lung-Video_Squamous_Lung_Cancer_Immunotherapy.m4v
Category:Lung-Cancer-Video -- posted at: 3:43pm PDT

Dr. David Spigel, Sarah Cannon Cancer Center, describes current research in immunotherapy as treatment for squamous lung cancer.

Direct download: GRACEcast-181_Lung-Audio_Squamous_Lung_Cancer_Immunotherapy.mp3
Category:Lung-Cancer-Audio -- posted at: 3:43pm PDT

Dr. David Spigel, Sarah Cannon Cancer Center, outlines treatment options for squamous lung cancer.

Direct download: GRACEcast-180_Lung-Video_Squamous_Lung_Cancer_Treatment.m4v
Category:Lung-Cancer-Video -- posted at: 3:08pm PDT

Dr. David Spigel, Sarah Cannon Cancer Center, outlines treatment options for squamous lung cancer.

Direct download: GRACEcast-180_Lung-Audio_Squamous_Lung_Cancer_Treatment.mp3
Category:Lung-Cancer-Audio -- posted at: 3:07pm PDT

Dr. David Spigel, Sarah Cannon Cancer Center, discusses the importance of genomic testing in squamous lung cancer.

Direct download: GRACEcast-179_Lung-Video_Squamous_Lung_Cancer_Genomic_Testing.m4v
Category:Lung-Cancer-Video -- posted at: 10:03am PDT

Dr. David Spigel, Sarah Cannon Cancer Center, discusses the importance of genomic testing in squamous lung cancer.

Direct download: GRACEcast-179_Lung-Audio_Squamous_Lung_Cancer_Genomic_Testing.mp3
Category:Lung-Cancer-Audio -- posted at: 10:02am PDT

Dr. David Spigel, Sarah Cannon Cancer Center, describes the diagnosis, presentation and workup of squamous lung cancer.


Dr. David Spigel, Sarah Cannon Cancer Center, describes the diagnosis, presentation and workup of squamous lung cancer.


Dr. Colin Weekes, pancreatic cancer specialist from the University of Colorado, reviews novel approaches, including nab-paclitaxel with gemcitabine, in advanced pancreatic cancer.


Dr. Colin Weekes, pancreatic cancer specialist from the University of Colorado, reviews novel approaches, including nab-paclitaxel with gemcitabine, in advanced pancreatic cancer.


Dr. Colin Weekes, pancreatic cancer specialist from the University of Colorado, discusses the history of and recent developments in chemotherapy for metastatic pancreatic cancer.


Dr. Colin Weekes, pancreatic cancer specialist from the University of Colorado, discusses the history of and recent developments in chemotherapy for metastatic pancreatic cancer.


Dr. Colin Weekes, pancreatic cancer specialist from the University of Colorado, covers the rationale and evidence for post-operative (adjuvant) therapy for resectable pancreatic cancer.


Dr. Colin Weekes, pancreatic cancer specialist from the University of Colorado, covers the rationale and evidence for post-operative (adjuvant) therapy for resectable pancreatic cancer.


Dr. Colin Weekes, pancreatic cancer specialist from the University of Colorado, covers the rationale and evidence for pre-operative (neoadjuvant) therapy for resectable pancreatic cancer.


Dr. Colin Weekes, pancreatic cancer specialist from the University of Colorado, reviews the differentiation between resectable and unresectable pancreatic cancer.


Dr. Colin Weekes, pancreatic cancer specialist from the University of Colorado, reviews the differentiation between resectable and unresectable pancreatic cancer.


Dr. Colin Weekes, pancreatic cancer specialist from the University of Colorado, reviews the differentiation between resectable and unresectable pancreatic cancer.


Dr. Edward Garon, David Geffen School of Medicine at UCLA, covers the provocative results of the novel immune checkpoint PD-L1 inhibitor MPDL3280A in advanced NSCLC.

Direct download: GRACEcast-172_Lung-Video_ASCO_2013_MPDL3280A_NSCLC.m4v
Category:Lung-Cancer-Video -- posted at: 12:33pm PDT

Dr. Edward Garon, David Geffen School of Medicine at UCLA, covers the provocative results of the novel immune checkpoint PD-L1 inhibitor MPDL3280A in advanced NSCLC.

Direct download: GRACEcast-172_Lung-Audio_ASCO_2013_MPDL3280A_NSCLC.mp3
Category:Lung-Cancer-Audio -- posted at: 12:32pm PDT

Dr. Edward Garon, David Geffen School of Medicine at UCLA, reviews impressive results from the GALAXY-1 trial of the heat shock protein inhibitor ganetespib combined with combined with second line docetaxel in advanced lung adenocarcinoma.

Direct download: GRACEcast-171_Lung-Video_ASCO_2013_Ganetespib_Second_Line.m4v
Category:Lung-Cancer-Video -- posted at: 6:58pm PDT

Dr. Edward Garon, David Geffen School of Medicine at UCLA, reviews impressive results from the GALAXY-1 trial of the heat shock protein inhibitor ganetespib combined with combined with second line docetaxel in advanced lung adenocarcinoma.

Direct download: GRACEcast-171_Lung-Audio_ASCO_2013_Ganetespib_Second_Line.mp3
Category:Lung-Cancer-Audio -- posted at: 6:56pm PDT

Dr. Edward Garon, David Geffen School of Medicine at UCLA, discusses results in a trial that demonstrated a significant survival benefit with nintedanib combined with second line docetaxel in advanced lung adenocarcinoma.

Direct download: GRACEcast-170_Lung-Video_ASCO_2013_Nintedanib_Second_Line.m4v
Category:Lung-Cancer-Video -- posted at: 4:57pm PDT

Dr. Edward Garon, David Geffen School of Medicine at UCLA, discusses results in a trial that demonstrated a significant survival benefit with nintedanib combined with second line docetaxel in advanced lung adenocarcinoma.

Direct download: GRACEcast-170_Lung-Audio_ASCO_2013_Nintedanib_Second_Line.mp3
Category:Lung-Cancer-Audio -- posted at: 4:56pm PDT

Dr. Edward Garon, David Geffen School of Medicine at UCLA, describes the exciting developments with LDK-378 and potentially other second generation ALK inhibitors for crizotinib-resistant ALK-positive advanced NSCLC.


Dr. Edward Garon, David Geffen School of Medicine at UCLA, describes the exciting developments with LDK-378 and potentially other second generation ALK inhibitors for crizotinib-resistant ALK-positive advanced NSCLC.


Dr. Edward Garon, David Geffen School of Medicine at UCLA, covers the results and implications of the MADeIT phase III randomized study of preductive biomarkers ERCC1 and RRM1 in advanced NSCLC.

Direct download: GRACEcast-168_Lung-Video_ASCO_2013_MADeIT_ERCC1_RRM1.m4v
Category:Lung-Cancer-Video -- posted at: 11:49am PDT

Dr. Edward Garon, David Geffen School of Medicine at UCLA, covers the results and implications of the MADeIT phase III randomized study of preductive biomarkers ERCC1 and RRM1 in advanced NSCLC.

Direct download: GRACEcast-168_Lung-Audio_ASCO_2013_MADeIT_ERCC1_RRM1.mp3
Category:Lung-Cancer-Audio -- posted at: 11:48am PDT

Dr. Edward Garon, David Geffen School of Medicine at UCLA, reviews the landmark Biomarkers France study that tested a wide range of molecular markers in NSCLC.

Direct download: GRACEcast-167_Lung-Video_ASCO_2013_Biomarkers_France.m4v
Category:Lung-Cancer-Video -- posted at: 11:47am PDT

Dr. Edward Garon, David Geffen School of Medicine at UCLA, reviews the landmark Biomarkers France study that tested a wide range of molecular markers in NSCLC.

Direct download: GRACEcast-167_Lung-Audio_ASCO_2013_Biomarkers_France.mp3
Category:Lung-Cancer-Audio -- posted at: 11:46am PDT

Dr. David Gerber, University of Texas-Southwestern, discusses the key results and potential implications of the CALGB 30504 trial of maintenance sunitinib for extensive stage SCLC.


Dr. David Gerber, University of Texas-Southwestern, discusses the key results and potential implications of the CALGB 30504 trial of maintenance sunitinib for extensive stage SCLC.


Dr. David Gerber, University of Texas-Southwestern, reviews the results of the PROSE study of the Veristrat serum proteomics test to predict benefit of chemo or EGFR inhibitor for second line treatment of advanced lung cancer.

Direct download: GRACEcast-165_Lung-Video_ASCO_2013_Veristrat_PROSE.m4v
Category:Lung-Cancer-Video -- posted at: 2:19pm PDT

Dr. David Gerber, University of Texas-Southwestern, reviews the results of the PROSE study of the Veristrat serum proteomics test to predict benefit of chemo or EGFR inhibitor for second line treatment of advanced lung cancer.

Direct download: GRACEcast-165_Lung-Audio_ASCO_2013_Veristrat_PROSE.mp3
Category:Lung-Cancer-Audio -- posted at: 2:18pm PDT

Dr. David Gerber, University of Texas-Southwestern, discusses results of two important trials of maintenance therapy in advanced NSCLC, including the PRONOUNCE trial and POINTBREAK trials.


Dr. David Gerber, University of Texas-Southwestern, discusses results of two important trials of maintenance therapy in advanced NSCLC, including the PRONOUNCE trial and POINTBREAK trials.


Dr. Rosalyn Juergens, McMaster University, provides her perspective on the likelihood that molecular oncology principles and targeted therapies will become more broadly applicable for other LC subtypes.


Dr. Greg Riely, from Memorial Sloan-Kettering, describes which patients with advanced NSCLC he seeks molecular marker testing on, and the particular markers he prioritizes.


Dr. Colin Weekes, pancreatic cancer specialist from the University of Colorado, covers the role of chemotherapy in pancreatic cancer, beginning with the molecular biology of pancreatic cancer.


Dr. Colin Weekes, pancreatic cancer specialist from the University of Colorado, covers the role of chemotherapy in pancreatic cancer, beginning with the molecular biology of pancreatic cancer.


Dr. David Gerber, University of Texas-Southwestern, reviews a Swiss study comparing tri-modality therapy with chemoradiation followed by surgery to chemo followed by surgery for stage IIIA NSCLC.


Dr. David Gerber, University of Texas-Southwestern, reviews a Swiss study comparing tri-modality therapy with chemoradiation followed by surgery to chemo followed by surgery for stage IIIA NSCLC.


Dr. David Gerber, University of Texas-Southwestern, reviews results of the START trial of tecemotide immunotherapy for stage III unresectable NSCLC.


Dr. David Gerber, University of Texas-Southwestern, reviews results of the START trial of tecemotide immunotherapy for stage III unresectable NSCLC.


Dr. David Gerber, University of Texas-Southwestern, reviews results from RTOG 0617 that help clarify the optimal dose of radiation for stage III unresectable NSCLC.


Dr. David Gerber, University of Texas-Southwestern, reviews results from RTOG 0617 that help clarify the optimal dose of radiation for stage III unresectable NSCLC.


Dr. David Gerber, University of Texas-Southwestern, reviews the current questions in managing locally advanced NSCLC with chemo/radiation as introduction to key issues addressed in trials from ASCO 2013.

Direct download: GRACEcast-159_Lung-Video_ASCO_2013_Intro_to_Stage_III_NSCLC.m4v
Category:Lung-Cancer-Video -- posted at: 10:09pm PDT

Dr. David Gerber, University of Texas-Southwestern, reviews the current questions in managing locally advanced NSCLC with chemo/radiation as introduction to key issues addressed in trials from ASCO 2013.

Direct download: GRACEcast-159_Lung-Audio_ASCO_2013_Intro_to_Stage_III_NSCLC.mp3
Category:Lung-Cancer-Audio -- posted at: 10:08pm PDT

Dr. Bob Doebele from the University of Colorado, offers his insights on how to approach a patient with gradual progression in a single site, especially in the brain, or more multifocal progression after a good initial response to a targeted agent.


Dr. Phil Bonomi, from Rush University, describes the generations of EGFR inhibitors beginning with Gefitinib (Iressa).


Dr. David Spigel, Sarah Cannon Cancer Center, describes which molecular markers he seeks for NSCLC patients.


Dr. Jared Weiss from the University of North Carolina, Chapel Hill reviews results from HPV-positive patients with head and neck cancer (HNSCC) from recent trials and describes emerging research in this population.

Direct download: GRACEcast-158_HeadNeck-Video_HPV_HNSCC_Clinical_Trials.m4v
Category:Head-Neck-Video -- posted at: 1:41pm PDT

Dr. Jared Weiss from the University of North Carolina, Chapel Hill reviews results from HPV-positive patients with head and neck cancer (HNSCC) from recent trials and describes emerging research in this population.

Direct download: GRACEcast-158_HeadNeck-Audio_HPV_HNSCC_Clinical_Trials.mp3
Category:Head-Neck-Audio -- posted at: 1:41pm PDT

Dr. Jared Weiss from the University of North Carolina, Chapel Hill introduces us to the human papilloma virus and its role as a cause and relevant prognostic factor for head and neck cancer (HNSCC).

Direct download: GRACEcast-157_HeadNeck-Video_HPV_Introduction_HNSCC_Weiss.m4v
Category:Head-Neck-Video -- posted at: 1:40pm PDT

GRACE, cancerGRACE, GRACEcast, Jared Weiss, Unveristy of North Carolina-Chapel Hill, UNC-Chapel Hill, induction therapy, neoadjuvant therapy, head and neck cancer, HNSCC, carbplatin, paclitaxel, cetuximab, Taxol, Erbitux, weekly

Direct download: GRACEcast-157_HeadNeck-Audio_HPV_Introduction_HNSCC_Weiss.mp3
Category:Head-Neck-Audio -- posted at: 1:40pm PDT

Dr. Jared Weiss from the University of North Carolina, reviews several options as induction therapy for head and neck cancer and focuses on the potential appeal and tolerability of the combination of weekly carboplatin and paclitaxel with cetuximab.

Direct download: GRACEcast-156_HeadNeck-Video_Induction_Chemo_HNSCC_Weiss_2.m4v
Category:Head-Neck-Video -- posted at: 10:42am PDT

Dr. Jared Weiss from the University of North Carolina, reviews several options as induction therapy for head and neck cancer and focuses on the potential appeal and tolerability of the combination of weekly carboplatin and paclitaxel with cetuximab.

Direct download: GRACEcast-156_HeadNeck-Audio_Induction_Chemo_HNSCC_Weiss_2.mp3
Category:Head-Neck-Audio -- posted at: 10:42am PDT

Dr. Jared Weiss from the University of North Carolina, Chapel Hill reviews the rationale for induction chemotherapy before surgery for head and neck cancer and highlights the early work that led to the emergence of the TPF regimen in this setting.

Direct download: GRACEcast-155_HeadNeck-Video_Induction_Chemo_HNSCC_Weiss_1.m4v
Category:Head-Neck-Video -- posted at: 2:06pm PDT

Dr. Jared Weiss from the University of North Carolina, Chapel Hill reviews the rationale for induction chemotherapy before surgery for head and neck cancer and highlights the early work that led to the emergence of the TPF regimen in this setting.

Direct download: GRACEcast-155_HeadNeck-Audio_Induction_Chemo_HNSCC_Weiss_1.mp3
Category:Head-Neck-Audio -- posted at: 2:05pm PDT

Dr. Ravi Salgia, from the University of Chicago, describes which patients with advanced non-small cell lung cancer he would recommend getting a repeat biopsy to obtain sufficient tissue to perform molecular marker testing.


Dr. Sarah Goldberg gives her view on more widespread availability of new mutation tests, provides her perspective on the likelihood that molecular oncology principles and targeted therapies will become more broadly applicable for other LC subtypes.


Dr. Bob Doebele from the University of Colorado, provides his view on the targeted therapy approaches most likely to become clinically useful in lung cancer over the next several years.


Drs. Ross Camidge and Corey Langer describe which patients with advanced NSCLC they seek molecular marker testing on.


Dr. Greg Riely, from Memorial Sloan-Kettering, gives her view on more widespread availability of new mutation tests.


Drs. Mary Pinder, Nate Pennell, and Jack West discuss whether the finding of improving progression-free survival with maintenance sorafenib for SCLC should change the standard of care for treatment of extensive stage disease.


Drs. Jack West, Mary Pinder, and Nate Pennell review various ways in which emerging immunotherapies could be effectively incorporated into our treatment strategies for lung cancer, potentially adding to or replacing current options.


Drs. Jack West, Mary Pinder, and Nate Pennell discuss options for managing acquired resistance to EGFR TKIs and ALK inhibitors in patients with advanced NSCLC and a driver mutation.


Drs. Nate Pennell, Mary Pinder, and Jack West discuss the START trial of L-BLP-25 (tecemotide) immunotherapy in locally advanced NSCLC.

Direct download: GRACEcastUC-146_Lung-Video_START_Trial_ASCO_2013.m4v
Category:Lung-Cancer-Video -- posted at: 11:35am PDT

Dr. Phil Bonomi, from Rush University, reviews his thought process in recommending a repeat biopsy after progression for patients with advanced lung cancer.


Dr. Rosalyn Juergens, McMaster University, reviews how she discusses the potential advantages and disadvantages waiting on molecular marker results and sometimes seeking additional tissue in patients with advanced NSCLC.


Drs. Mary Pinder, Nate Pennell, and Jack West discuss developments with selumetinib and other MEK inhibitors as a potential target for the 20-25% of NSCLC patients with a KRAS mutation.

Direct download: GRACEcastUC-144_Lung-Video_MEK_Inhibitor_Update_ASCO_2013.m4v
Category:Lung-Cancer-Video -- posted at: 11:43pm PDT

Dr. Geoffrey Oxnard, Dana Farber Cancer Institute, describes which patients with advanced non-small cell lung cancer he would recommend getting a repeat biopsy to obtain sufficient tissue to perform molecular marker testing.


Drs. Nate Pennell, Mary Pinder, and Jack West discuss an encouraging study of dabrafenib, a BRAF inhibitor, for the limited number of NSCLC patients with a BRAF V600E mutation.


Dr. Mary Pinder of Moffitt Cancer Center reviews the CUSTOM trial, in which the study of molecular markers was expanded to patients with small cell lung cancer and thymic carcinomas.


Dr. David Spigel gives his view on more widespread availability of new mutation tests, provides his perspective on the likelihood that molecular oncology principles and targeted therapies will become more broadly applicable for other lung cancer subtypes.


Dr. Heather Wakelee, from Stanford University, describes which molecular markers she seeks for NSCLC patients.


Dr. Nate Pennell from Cleveland Clinic reviews the LUME Lung-1 trial presented by Reck at ASCO 2013, of Taxotere with or without nindetanib (BIBF-1120), an anti-angiogenic multikinase inhibitor, in advanced NSCLC.

Direct download: GRACEcastUC-139_Lung-Video_Nindetanib_BIBF1120_LUME_Lung-1.m4v
Category:Lung-Cancer-Video -- posted at: 4:09pm PDT

Dr. Mary Pinder reviews promising studies from ASCO 2013 on second gen. ALK inhibitors LDK-378, CH5424802, and AP26113 in patients with ALK-positive advanced NSCLC, including impressive activity in crizotinib-refractory patients and those with brain mets.

Direct download: GRACEcastUC-137_Lung-Video_Second_Generation_ALK_Inhibitors.m4v
Category:Lung-Cancer-Video -- posted at: 4:09pm PDT

Drs. Mary Pinder, Nate Pennell, and Jack West discuss promising work on immune checkpoint inhibitors such as MPPL-3280A, an anti-PDL1 immune-based therapy, and anti-PD1 therapy nivolumab, in advanced NSCLC.

Direct download: GRACEcastUC-136_Lung-Video_MPDL3280A_Spigel_ASCO_2013_NSCLC.m4v
Category:Lung-Cancer-Video -- posted at: 6:01pm PDT

Drs. Mary Pinder, Nate Pennell, and Jack West discuss the results presented at ASCO 2013 of the GALAXY-1 trial of the HSP90 inhibitor ganetespib combined with Taxotere (docetaxel) as second line therapy for advanced NSCLC.

Direct download: GRACEcastUC-134_Lung-Video_GALAXY-1_Ganetespib_HSP90.m4v
Category:Lung-Cancer-Video -- posted at: 6:01pm PDT

Dr. Larry Einhorn, Distinguished Professor of Medicine at Indiana Univ and former ASCO president, discusses the trend of patients consulting Dr.Google - finding information of varied quality on the internet.


Dr. Karen Kelly, of the University of California, Davis, gives her view on more widespread availability of new mutation tests.


Drs. Nate Pennell, Mary Pinder, and Jack West review the results presented at ASCO 2013 from the PARAMOUNT trial of maintenance therapy with the ECOG 4599 regimen vs. carboplatin/Alimta (pemetrexed)/Avastin (bevacizumab) followed by Alimta/Avastin maint.


Drs. Nate Pennell, Mary Pinder, and Jack West review the results presented at ASCO 2013 from the PRONOUNCE trial of the ECOG 4599 trial regimen compared with carboplatin/Alimta (pemetrexed) followed by maintenance Alimta. 

Direct download: GRACEcastUC-131_Lung-Video_PRONOUNCE_Trial.m4v
Category:Lung-Cancer-Video -- posted at: 5:45pm PDT

Dr. Phil Bonomi, from Rush University, describes which patients with advanced non-small cell lung cancer he would recommend getting a repeat biopsy to obtain sufficient tissue to perform molecular marker testing.


Drs. Mary Pinder, Nate Pennell, and Jack West review results from the PROSE trial presented at ASCO 2013, testing the predictive value of the Veristrat test of serum proteomics to assess the potential value of erlotinib (Tarceva) in advanced NSCLC.

Direct download: GRACEcastUC-129_Lung-Video_PROSE_Trial_Veristrat.m4v
Category:Lung-Cancer-Video -- posted at: 7:05pm PDT

Drs. Ross Camidge and Corey Langer describe their practice when patients with advanced NSCLC bring them the results of broad molecular marker testing.


Drs. Nate Pennell, Mary Pinder, and Jack West discuss trials presented at ASCO 2013 testing the potential value of molecular marker testing to select optimal chemo for advanced non-small cell lung cancer (NSCLC).


Dr. Antoinette (Toni) Wozniak from Karmanos Cancer Center in Detroit, MI discusses the evolution of our current best treatments for limited and extensive stage small cell lung cancer, as well as emerging potential therapies.


Dr. Antoinette (Toni) Wozniak from Karmanos Cancer Center in Detroit, MI discusses the evolution of our current best treatments for limited and extensive stage small cell lung cancer, as well as emerging potential therapies.


Drs. Nate Pennell, Mary Pinder, and Jack West discuss the Biomarkers France trial of testing on a national scale for clinically relevant biomarkers in advanced non-small cell lung cancer (NSCLC).


Dr. Greg Riely, from Memorial Sloan-Kettering, provides his perspective on the likelihood that molecular oncology principles and targeted therapies will become more broadly applicable for patients with squamous and other lung cancer subtypes.


Dr. Geoffrey Oxnard, Dana Farber Cancer Institute, reviews his thought process in recommending a repeat biopsy after progression for patients with advanced lung cancer.


Dr. Rosalyn Juergens, McMaster University, discusses the evidence and her personal interpretation and recommended approach to maintenance therapy for advanced non-small cell lung cancer.


Dr. Sarah Goldberg from Yale Cancer Center describes which patients with advanced NSCLC she seeks molecular marker testing on.


Dr. Ravi Salgia from the University of Chicago discusses the trend of patients consulting Dr.Google - finding information of varied quality on the internet.


Dr. Antoinette (Toni) Wozniak from Karmanos Cancer Center in Detroit, MI reviews the impact, causes, common symptoms, and approach to staging of small cell lung cancer.


Dr. Antoinette (Toni) Wozniak from Karmanos Cancer Center in Detroit, MI reviews the impact, causes, common symptoms, and approach to staging of small cell lung cancer.